YuliaNuzhnenko

Vcf Annotation — Development skill for Claude Code

Development community

Agent Skill: Clinical VCF Variant Annotator.

How to install Vcf Annotation

Installs to ~/.claude/skills/yulianuzhnenko-bioinformatics-agent-skills-vcf_annotation/SKILL.md

Terminal

mkdir -p ~/.claude/skills/yulianuzhnenko-bioinformatics-agent-skills-vcf_annotation && curl -fsSL https://raw.githubusercontent.com/YuliaNuzhnenko/bioinformatics-agent-skills/HEAD/skills/vcf_annotation.md -o ~/.claude/skills/yulianuzhnenko-bioinformatics-agent-skills-vcf_annotation/SKILL.md

Restart Claude Code, or start a new session, for it to be picked up.

What Vcf Annotation does

Agent Skill: Clinical VCF Variant Annotator

name: vcf-variant-annotator
version: 1.0.0
domain: Clinical Genomics & Precision Oncology

Agent Protocol

When a user provides a VCF variant entry or coordinates:

Extract Chromosome, Position, Reference, and Alternate alleles.
Query NCBI ClinVar REST API for clinical significance classification (Pathogenic, VUS, Benign).
Retrieve Ensembl VEP REST API functional consequences (SIFT/PolyPhen-2 scores).
Map detected driver mut

Alternatives in Development

Healthcare — Skills for healthcare workflows including clinical trials, prior authorization review, and FHIR API developmen 204 ★
New Op — Guide for adding a new variant to the Op enum (e.g. Op::Tag, Op::Link) 201 ★
Bench Capture — Score the 2 bench variant folders for one size (build/acceptance/regression/conventions/capture + rubric + cro 85 ★